Award
National Institute on Drug Abuse 5R01DA056113-04
Estradiol signaling pathways mediating sex differences in striatal synaptic plasticity
Recipient
University of Iowa
Award Amount
$569,946.00
Ceiling
$569,946.00
Awarded
February 19, 2026
Identifier
5R01DA056113-04
Research project funded by NIDA to study estradiol's role in sex differences in striatal synaptic plasticity related to substance use disorders, using advanced scientific methods.
Description
This project investigates how estradiol interacts with cocaine to modify synaptic plasticity in the dorsal striatum, focusing on signaling pathways involved in long-term potentiation impairment in specific striatal neurons and the influence of cocaine. The study uses molecular, electrophysiological, and computational modeling techniques to understand sex differences in substance use disorders.