Award
National Institute of General Medical Sciences 5R01GM151731-04
URIL tags for intracellular RNA tracking and RNP proximity labeling
Recipient
Ohio State University
Award Amount
$364,674.00
Ceiling
$364,674.00
Awarded
September 27, 2023
Identifier
5R01GM151731-04
Development of chemical probes for RNA research related to neurodegenerative diseases such as ALS, focusing on intracellular RNA tracking and proximity labeling using bifacial peptide nucleic acids.
Description
This project aims to develop and evaluate bifacial peptide nucleic acids (bPNAs) targeting URIL motifs in structured RNAs for intracellular RNA tracking and proximity labeling, with a focus on ALS-related RNP biology.