Award
National Institute on Drug Abuse 1U01DA064170-01
Long term impact of maternal opioid use and management strategies on neurodevelopment in rodent offspring
Recipient
Washington University, Saint Louis, MO
Award Amount
$733,457.00
Ceiling
$733,457.00
Awarded
April 13, 2026
Identifier
1U01DA064170-01
A NIH-funded research project investigating the long-term neurodevelopmental effects of maternal opioid use and treatment strategies on rodent offspring, focusing on behavioral, structural brain changes, and reward processing.
Description
This project aims to evaluate the long-term impact of in utero oxycodone exposure, opioid maintenance therapy, and withdrawal mitigation strategies on neuro-behavioral development, brain structure, volume, and reward processing. It addresses concerns about neurodevelopmental outcomes such as lower social competence, memory deficits, and behavioral problems linked to in utero opioid exposure. The study will assess the effects of therapies like methadone and buprenorphine on offspring, analyze brain changes via MRI, and explore circuit-level reward processing alterations.