Award
National Cancer Institute 7R01CA262873-05
Mdm2 Alternative Splicing in DNA Damage and Cancer
Recipient
Ohio State University, Columbus, OH
Award Amount
$464,185.00
Ceiling
$464,185.00
Awarded
September 11, 2025
Identifier
7R01CA262873-05
This NIH grant funds research on the role of MDM2 alternative splicing in cancer, focusing on mechanisms of MDM2-ALT1 generation and therapeutic targeting to control the p53 pathway.
Description
Study of the control of the p53 pathway by MDM2-ALT1 to understand its generation in cancer and targeting using splice-switching oligonucleotides. The research aims to identify RNA sequences and nuclear factor-binding partners necessary for regulation of MDM2 splicing and to modulate MDM2 isoform levels using mouse models and splice switching oligonucleotides.