Award
NIH Reporter #1R01HL172902-01A1
Alternative polyadenylation regulation in cardiac fibrosis
Recipient
Methodist Hospital Research Institute, Houston, TX, United States
Award Amount
$789,693.00
Ceiling
$789,693.00
Awarded
August 15, 2026
Identifier
1R01HL172902-01A1
Research project funded by the National Heart Lung and Blood Institute to study alternative polyadenylation's role in cardiac fibrosis and develop potential RNA-based therapies for heart failure.
Description
This project investigates the role of alternative polyadenylation (APA) in regulating fibrotic gene expression, focusing on the depletion of NUDT21 and its impact on 3'UTR shortening and fibrosis. The research aims to elucidate molecular mechanisms and explore therapeutic strategies to reverse fibroblast activation and promote myocardial recovery.