Award
National Institute of Arthritis and Musculoskeletal and Skin Diseases 5R01AR082979-03
Engineering a Human Skeletal Muscle Tissue Model of LGMD2B
Recipient
Duke University
Award Amount
$480,947.00
Ceiling
$480,947.00
Awarded
August 21, 2025
Identifier
5R01AR082979-03
NIH grant awarded to Duke University to develop a 3D human skeletal muscle tissue model of LGMD2B for disease modeling and drug discovery, funded by NIAMS with an award amount of $480,947 for the period 2023-2028.
Description
The project aims to engineer a 3D human skeletal muscle tissue model replicating LGMD2B features using iPSC lines from donors, to study fat accumulation, immune interactions, and cholesterol metabolism in LGMD2B. It focuses on developing advanced in vitro models for LGMD2B to facilitate mechanistic understanding and drug discovery, involving tissue engineering, stem cell research, immunology, and metabolic studies.