Award
NIH Reporter #5K08EB037675-02
Modular, degradable, polymeric nanoparticles for the treatment of phagocyte-mediated diseases
Recipient
Yale University, New Haven, CT
Award Amount
$191,300.00
Ceiling
$191,300.00
Awarded
July 07, 2026
Identifier
5K08EB037675-02
Award for research on biodegradable polymeric nanoparticles targeting phagocyte-mediated diseases, aiming to improve drug delivery and treatment efficacy for conditions like antibody-mediated erythrophagocytosis.
Description
This project focuses on the development of biodegradable poly(amine-co-ester) (PACE) nanoparticles designed to deliver therapeutic nucleic acids to phagocyte subpopulations in the liver and spleen, aiming to treat phagocyte-mediated diseases such as antibody-mediated erythrophagocytosis. The research will study how nanoparticle design influences drug biodistribution and uptake in health and disease contexts.