Award
National Institute of General Medical Sciences 5R16GM145429-04
Nematicidal Chalcones: A Genetic Approach to Uncovering the Action Mechanism
Recipient
California State University Fresno
Award Amount
$136,000.00
Ceiling
$136,000.00
Awarded
June 12, 2025
Identifier
5R16GM145429-04
A research project funded by NIH NIGMS to study the mechanisms of action of chalcone compounds as nematicidal agents using genetic screening in C. elegans, with the goal of developing effective nematicidal agents with minimal environmental impact.
Description
This project aims to characterize novel chalcone nematicidal agents and elucidate their mechanisms of action by conducting forward genetic screens on mutagenized C. elegans to identify mutants resistant to chalcones, characterizing these mutants, and identifying the involved DNA sequences.