Award
National Heart, Lung, and Blood Institute 1K08HL171943-01A1
Lymph Node Stromal Cells in the Pathogenesis, Diagnosis, and Treatment of Unicentric Castleman Disease
Recipient
University of Pennsylvania
Award Amount
$169,020.00
Ceiling
$169,020.00
Awarded
August 15, 2025
Identifier
1K08HL171943-01A1
Research project funded to study lymph node stromal cells' role in Castleman Disease, focusing on clonal expansion and PDGFRB mutations to improve diagnosis and treatment.
Description
The project aims to investigate the role of lymph node stromal cells in Castleman Disease, a rare lymphoproliferative disorder. The research will focus on whether clonal expansion of these cells contributes to disease pathogenesis, particularly examining PDGFRB mutations and their effects on cytokine production and lymphoproliferation. The study involves determining cellular identity, clonality, and functional consequences of mutations, with the goal of developing better diagnostics and therapies.