Award
NIH Reporter #4R01NS128738-02
Defining the Role of Enteric Nervous System Dysfunction in Gastrointestinal Motor and Sensory Abnormalities in Down Syndrome
Recipient
National Institute of Neurological Disorders and Stroke (NINDS), NIH
Award Amount
$1,022,869.00
Ceiling
$1,022,869.00
Awarded
May 07, 2026
Identifier
4R01NS128738-02
NIH awarded a grant to study the role of enteric nervous system dysfunction in gastrointestinal abnormalities in Down syndrome, aiming to develop therapies to reduce neuro-intestinal disease.
Description
The project focuses on gastrointestinal conditions in individuals with Down syndrome, particularly the role of the enteric nervous system. The project involves deep-phenotyping and animal research using mouse models and aims to develop ENS-based therapies to reduce neuro-intestinal disease in the DS population.