Award
National Institute of Allergy and Infectious Diseases 5R21AI174034-02
Role of Lung Repair and Regeneration Pathways in Tuberculosis
Recipient
University of Chicago
Award Amount
$205,000.00
Ceiling
$205,000.00
Awarded
July 23, 2025
Identifier
5R21AI174034-02
A research project funded by NIAID to study lung repair and regeneration pathways in tuberculosis, focusing on BMP signaling during TB latency to develop therapeutic strategies.
Description
This project aims to delineate the cellular mechanisms of protective pathways that mediate Mycobacterium tuberculosis control and tuberculosis reactivation, focusing on lung tissue repair and regeneration during tuberculosis latency. The study hypothesizes that during tuberculosis latency, BMP signaling is upregulated, mediating lung tissue repair, regeneration, and Mtb control. Specific aims include determining the functional role of the BMP pathway in Mtb control and TB reactivation and characterizing the cellular mechanisms of BMP-pathway activation during TB latency.