Award
National Institute of Allergy and Infectious Diseases 5R33AI161805-05
Combinatorial and computational design of bnAb mRNA vaccines for HIV
Recipient
Massachusetts Institute of Technology
Award Amount
$771,167.00
Ceiling
$771,167.00
Awarded
June 06, 2025
Identifier
5R33AI161805-05
This NIH-funded project aims to develop innovative HIV mRNA vaccines that elicit broadly neutralizing antibodies by using computational design and biomimetic delivery methods, including lipid nanoparticles targeting lymph nodes. The research combines expertise in immunology, bioengineering, and mRNA therapeutics to address challenges in HIV vaccine development.
Description
Development of a new class of HIV mRNA vaccine candidates by combining computational antigen design, HIV immunology, combinatorial chemistry, and mRNA therapeutics. The project emphasizes biomimetic vaccine engineering, lymph node targeted delivery, and the use of lipid nanoparticles to induce broadly neutralizing antibodies (bnAbs) against HIV.