NIH Reporter #1R21NS151357-01

Sleep-driven reorganization of excitatory and inhibitory synaptic nanoarchitecture

The award supports research on how sleep affects the nanoscale organization of synaptic proteins in the brain, using advanced imaging techniques to study synaptic changes in mouse brain slices, with implications for understanding brain health and neurological conditions.

Description

This project aims to understand how sleep and sleep disruption influence the nanoscale organization of synaptic proteins, which regulate synaptic function and plasticity. Using stimulated emission depletion (STED) nanoscopy, the study will visualize synaptic nanoarchitecture in mouse brain slices, focusing on excitatory and inhibitory synapses in the primary visual cortex. The findings will shed light on mechanisms by which sleep modifies synaptic function, providing insights into sleep's role in brain health and disease.

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