Award
NIH Reporter #5R01NS136214-02
Spreading Depolarization and Progression of Developmental Epileptic Encephalopathy
Recipient
Baylor College of Medicine
Award Amount
$400,000.00
Ceiling
$400,000.00
Awarded
March 30, 2026
Identifier
5R01NS136214-02
Research project awarded to study the role of spreading depolarization in epilepsy progression using a mouse model of Dravet syndrome, involving electrophysiological and behavioral analyses.
Description
This project investigates the role of spreading depolarization in epilepsy, focusing on its contribution to disease progression and comorbidities in a mouse model of Dravet syndrome. The study involves electrophysiological monitoring, behavioral analysis, and examination of hippocampal SD during early-life hyperthermic seizures.