Award
National Institute of Arthritis and Musculoskeletal and Skin Diseases 1R21AR086493-01A1
Modulation of efferocytosis in systemic sclerosis
Recipient
University of Virginia, Charlottesville, VA, United States
Award Amount
$377,506.00
Ceiling
$377,506.00
Awarded
June 03, 2026
Identifier
1R21AR086493-01A1
Research project funded by NIAMS to study the role of efferocytosis modulation in systemic sclerosis fibrosis using mouse models, aiming to develop therapeutic strategies.
Description
This project aims to test the impact of dead cell clearance modulation on tissue fibrosis using models of systemic sclerosis, including bleomycin-induced mouse models of skin and lung fibrosis. It investigates how modulation of efferocytosis affects the development and severity of fibrosis, hypothesizing that reduced or measured efferocytosis may prevent excessive fibrosis.