National Heart, Lung, and Blood Institute 5R01HL157776-04

Pathogenic monocyte response to chronic lung inflammation in cystic fibrosis

NIH awarded a research project to Yale University to study the role of inflammatory monocytes in chronic lung inflammation in cystic fibrosis, aiming to understand immune mechanisms and tissue remodeling.

Description

Researchers aim to understand the mechanisms behind progressive and irreversible lung damage in cystic fibrosis (CF). The study involves developing a CF mouse model of chronic inflammation to investigate how inflammatory monocytes contribute to lung tissue remodeling. The research hypothesizes that chronic exposure to lipopolysaccharide (LPS) increases recruitment of inflammatory monocytes, which cause tissue damage while failing to fight infection, initiated by loss of CFTR function in hematopoietic stem/progenitor cells.

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