Award
NIH Reporter #5P01HL139420-08
Structural Correlates of (Pro)Cofactor Function
Recipient
Children's Hospital of Philadelphia
Award Amount
$491,683.00
Ceiling
$491,683.00
Awarded
July 24, 2026
Identifier
5P01HL139420-08
A research project funded by the National Heart Lung and Blood Institute to study the structure and function of blood coagulation factor V, aiming to improve understanding and treatment of bleeding and thrombosis.
Description
This project aims to understand the structural and functional aspects of factor V and its variants to develop therapeutic strategies for blood coagulation disorders. The research focuses on the activation and regulation of blood coagulation factor V, its procoagulant and anticoagulant roles, and the development of antibodies to modulate its functions.