Award
NIH Reporter #5R01AR044882-27
Transcriptional Co-Regulators in Epidermis
Recipient
University of California-Irvine
Award Amount
$549,585.00
Ceiling
$549,585.00
Awarded
September 01, 2026
Identifier
5R01AR044882-27
NIH grant awarded to University of California-Irvine to study gene regulatory networks and transcription factors in epidermal differentiation using advanced transcriptomics and computational methods.
Description
This project aims to study the cellular composition, gene expression, and cell-cell signaling in the epidermis, focusing on basal-to-spinous transition cells. Using single-cell and spatial transcriptomics, along with chromatin mapping and computational modeling, the research will investigate gene regulatory networks and the role of transcription factors in epidermal differentiation. The work addresses a novel cell state in epidermal biology, which has not been previously explored.