Award
National Cancer Institute 5U01CA275301-04
B cell determinants of EBV latency
Recipient
Weill Medical College of Cornell University
Award Amount
$827,246.00
Ceiling
$827,246.00
Awarded
September 18, 2025
Identifier
5U01CA275301-04
The project studies the epigenetic mechanisms controlling EBV latency and viral oncoprotein expression in B cells, aiming to develop therapeutic approaches for EBV-driven lymphomas, particularly in HIV co-infected individuals.
Description
This project investigates how the biology of B cells determines viral protein expression, how the virus affects B cell biology, and how these events lead to lymphoma development, with a focus on Epstein-Barr Virus (EBV) and its role in B cell lymphomas, especially in the context of HIV co-infection.