Award
NIH Reporter #5UH3NS128150-05
Neurostimulation of the Nucleus Basalis of Meynert for the Cognitive-Motor Syndrome in Parkinson's Disease
Recipient
Stanford University
Award Amount
$1,070,731.00
Ceiling
$1,070,731.00
Awarded
August 24, 2026
Identifier
5UH3NS128150-05
This award funds a pilot clinical trial to test the safety and feasibility of combined STN and intermittent NBM deep brain stimulation to address cognitive-motor impairment in Parkinson's disease patients.
Description
The project aims to establish the safety, tolerability, and feasibility of combined continuous subthalamic nucleus (STN) and intermittent NBM deep brain stimulation (DBS) for people with Parkinson’s disease and mild cognitive and cognitive-motor impairment using novel tractography defined targets and patterned stimulation. The study involves a pilot clinical trial with 10 participants receiving STN + NBM DBS, with primary outcomes measured at 12 months, including behavioral, cognitive, and PET imaging assessments.