Award
National Cancer Institute 5R01CA239719-06
Effects of chronic pubertal stressors on mammary gland biology and cancer risk
Recipient
University of Chicago
Award Amount
$462,106.00
Ceiling
$462,106.00
Awarded
June 05, 2025
Identifier
5R01CA239719-06
This NIH-funded research investigates the impact of chronic pubertal stress on mammary gland development and breast cancer risk using a rat model, aiming to understand molecular mechanisms and test interventions to reduce cancer risk.
Description
Using a rat model of human breast development and cancer, this project studies how increased stress hormone reactivity from continuous social isolation disrupts mammary gland development and stem cell differentiation, increasing breast cancer risk. It also tests pharmacological or social interventions to restore normal development and reduce cancer risk.