Award
National Institute of Allergy and Infectious Diseases 5R37AI167750-04
Genetic and hormonal mechanisms mediating sex differences in TB and TB-HIV
Recipient
Johns Hopkins University, Baltimore, MD
Award Amount
$813,838.00
Ceiling
$813,838.00
Awarded
January 23, 2026
Identifier
5R37AI167750-04
A research project funded by NIAID to study genetic and hormonal factors contributing to sex differences in tuberculosis and TB-HIV co-infection, using advanced molecular tools and animal models to understand immune response variations between males and females.
Description
This project investigates the biological mechanisms underlying the male bias in tuberculosis (TB) and TB-HIV co-infection, focusing on genetics (X chromosome complement) and sex steroid hormones using cellular tools, animal models, and human samples. The study aims to differentiate the impact of genetics from sex steroids on TB pathogenesis, explore gene escape from X-chromosome inactivation as a cause of male bias in TB severity, and assess the intersection of HIV infection and sex differences in immunity.