Award
National Cancer Institute 5K22CA282363-02
Targeting mitochondrial oxygen demand to overcome hypoxic immune privilege of NSCLC tumors
Recipient
Ohio State University, Columbus, OH
Award Amount
$183,398.00
Ceiling
$183,398.00
Awarded
August 11, 2025
Identifier
5K22CA282363-02
The award supports research to understand and overcome hypoxic immune privilege in non-small cell lung cancer (NSCLC) tumors by targeting mitochondrial oxygen demand, enhancing tumor response to immunotherapy.
Description
This project aims to investigate the role of tumor hypoxia as a modulator of immune privilege in murine NSCLC models and develop strategies to improve immunotherapy outcomes by overcoming hypoxia-induced immune suppression in lung cancer through mitochondrial modulation and immune checkpoint blockade.