Award
NIH Reporter #1R01DK144010-01A1
The Role of Epithelial MicroRNAs to Confer Sex-Specific Renoprotection in Acute Kidney Injury
Recipient
University of Pittsburgh at Pittsburgh, PA, United States
Award Amount
$711,430.00
Ceiling
$711,430.00
Awarded
July 23, 2026
Identifier
1R01DK144010-01A1
NIH-funded research project studying how microRNAs contribute to sex-specific protection in acute kidney injury, aiming to uncover mechanisms that could lead to sex-specific therapies.
Description
This project investigates sex differences in microRNA regulation in tubular epithelial cells during acute kidney injury (AKI), hypothesizing that sex-differentially expressed microRNAs repress proinflammatory and profibrotic signaling pathways in female tubular epithelium. The study uses human kidney cells and murine models to define the role of the miR-17~92 cluster in protecting against ischemic AKI and driving sex differences in injury response.