Award
National Eye Institute 5R01EY032080-05
miR-92a as a biomarker of diabetic retinopathy
Recipient
Indiana University Indianapolis, School of Medicine, Department of Ophthalmology
Award Amount
$539,499.00
Ceiling
$539,499.00
Awarded
August 01, 2025
Identifier
5R01EY032080-05
The award funds research to validate miR-92a as a biomarker for diabetic retinopathy by studying RNA and inflammation markers in circulating angiogenic cells and using rodent models to understand disease progression.
Description
This project proposes that RNA levels (mRNA and miRNA) and inflammation markers in circulating angiogenic cells (CACs) can serve as biomarkers for diabetic retinopathy (DR). RNA sequencing of CACs in DR patients will be performed, and the role of miRNA, specifically miR-92a, will be studied using rodent models. The project aims to validate miR-92a as a candidate biomarker and understand its role in DR progression.