National Institute of General Medical Sciences 5R01GM148535-03

Regulation of Adherent Cell Proliferation by Matrix Viscoelasticity

This NIH grant funds research at Stanford University to study how matrix stiffness and viscoelasticity regulate cell proliferation in 3D environments using biophysical methods, genome-wide analyses, and CRISPR screens, aiming to understand underlying mechanisms relevant to tissue development and disease.

Description

Extracellular matrix stiffness and viscoelasticity regulate cell proliferation in 3D microenvironments through mechanotransduction, but the mechanisms mediating these effects remain largely unclear. The research combines biophysical approaches with genome-wide analyses and CRISPR screens to determine the mechanisms mediating the impact of matrix stiffness and viscoelasticity on cell proliferation. The work aims to uncover biophysical and molecular mechanisms by which ECM or biomaterial stiffness and viscoelasticity influence cell proliferation in 3D.

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