Award
NIH Reporter #1OT2CA320056-01
CAUSE - Connecting DNA Adducts, Unexplained Mutational Signatures, and Cancer Etiologies
Recipient
University of California, San Diego
Award Amount
$1,143,033.00
Ceiling
$1,143,033.00
Awarded
June 11, 2026
Identifier
1OT2CA320056-01
This award funds a project to link DNA adducts to mutational signatures in cancer genomes using advanced technologies and AI, aiming to improve cancer understanding and treatment.
Description
The CAUSE project aims to identify specific DNA adducts and link them to mutational signatures using a high-throughput platform integrating chemistry, biology, genomics, and AI. The project focuses on endogenous processes, environmental exposures, and chemotherapy-induced adducts. It will involve mass spectrometry, structural analysis, genome-wide lesion mapping, reporter assays, biochemical studies, animal models, and AI modeling. The goal is to create a mechanistic atlas linking DNA adducts to mutational signatures, advancing cancer prevention, diagnosis, and treatment.