Award
National Institute of Neurological Disorders and Stroke 5R01NS120745-03
Fundamental Biology of Neuronal Extracellular Vesicles
Recipient
Rutgers, The State University of New Jersey
Award Amount
$392,500.00
Ceiling
$392,500.00
Awarded
July 29, 2025
Identifier
5R01NS120745-03
This award funds research on the role of neuronal extracellular vesicles in Alzheimer's disease, focusing on their regulation and function in disease progression and neuron-glia communication.
Description
Extracellular vesicles (EVs) carry Aβ and tau that may spread pathogenic proteins across the brain, promote Aβ aggregation, and accelerate amyloid plaque formation. EVs from blood, cerebrospinal fluid, and cell culture contain Aβ and tau and are proposed to be central mediators in Alzheimer's disease pathology. EVs may also have benefits, such as promoting uptake of Aβ by microglia and reducing extracellular Aβ levels. The research aims to study how neuronal EV shedding is modulated by factors like age, oxidative stress, and proteostasis, and to understand their roles in neuron-glia communication and disease progression.