Award
NIH Reporter #1R01DK148251-01
Alterations to adipose tissue regulation and function by cART in SIV-infected rhesus macaques
Recipient
University of Illinois at Urbana-Champaign
Award Amount
$882,709.00
Ceiling
$882,709.00
Awarded
September 01, 2026
Identifier
1R01DK148251-01
Research project funded by NIDDK to study the effects of HIV and antiretroviral therapy on adipose tissue function using a rhesus macaque model, aiming to understand mechanisms behind obesity and lipodystrophy in HIV patients.
Description
This project investigates how SIV and cART-mediated dysfunction in adipose tissue and adipose stem cells contributes to increased obesity in people living with HIV. It uses a rhesus macaque/SIV-infection model to test the hypothesis that both the virus and antiretroviral drugs contribute to accelerated aging and adipose tissue dysfunction. The study involves longitudinal assessment with advanced imaging and molecular techniques to elucidate mechanisms of adipose tissue dysfunction related to HIV treatment.