Award
National Institute of General Medical Sciences 5R35GM146664-05
Structural and Functional Characterization of RhoGEF Regulation Using Nanodiscs to Assemble Membrane-associated Signaling Scaffolds
Recipient
University of California at Davis
Award Amount
$388,705.00
Ceiling
$388,705.00
Awarded
June 08, 2026
Identifier
5R35GM146664-05
NIH grant awarded to University of California at Davis to study RhoGEF proteins' regulation and function using nanodiscs and cryo-EM, aiming to identify therapeutic targets related to cancer.
Description
This project aims to understand how RhoGEF proteins signal and are regulated, facilitating therapeutic development. It focuses on the P-Rex subfamily, including P-Rex1 and P-Rex2, which regulate cell migration and are associated with human cancers. The research explores their regulatory mechanisms, activation states, and scaffolding functions at the cell membrane using cryo-EM and nanodiscs to identify regulatory surfaces for therapeutic targeting.