Award
National Institute of Allergy and Infectious Diseases 5R01AI159452-05
THE ROLE OF THE NON-CANONICAL INFLAMMASOME IN INNATE IMMUNITY
Recipient
Ohio State University
Award Amount
$726,247.00
Ceiling
$726,247.00
Awarded
May 14, 2025
Identifier
5R01AI159452-05
Research project funded by NIAID to study the role of caspase-11 in innate immunity against Legionella pneumophila, focusing on molecular mechanisms of bacterial clearance in macrophages.
Description
This project aims to elucidate the molecular mechanisms of caspase-11 in innate immunity against Legionella pneumophila, utilizing advanced microscopy, sequencing, and proteomics techniques. Legionella pneumophila is an infectious bacterium that causes Legionnaire’s disease and remains a major cause of morbidity and mortality in the immunocompromised such as the elderly. Caspase-11 regulates bacterial clearance via mechanisms involving actin polymerization and lysosomal fusion, which are critical for immune defense.