Award
National Institute of Allergy and Infectious Diseases 5R37AI195421-02
Therapeutic vaccination to boost autologous neutralizing antibodies for ART free HIV Control
Recipient
University of Pennsylvania, Philadelphia, PA
Award Amount
$881,967.00
Ceiling
$881,967.00
Awarded
July 14, 2026
Identifier
5R37AI195421-02
This award supports research to develop a personalized mRNA-LNP vaccine to enhance autologous neutralizing antibody responses in HIV patients after early ART initiation, aiming for ART-free viral control. The study uses a nonhuman primate model to test vaccine efficacy and inform HIV cure strategies.
Description
Development of a personalized, mRNA-LNP therapeutic vaccine strategy to boost existing autologous neutralizing antibody responses in people with HIV following early antiretroviral therapy initiation to enhance virologic control. The study involves testing in SHIV-infected rhesus macaques to elicit antibody-mediated ART-free remission.