Award
National Institute of Allergy and Infectious Diseases 5R01AI121244-11
Redefining the role of autophagy in bacterial disease
Recipient
University of Pennsylvania, Philadelphia, PA, United States
Award Amount
$573,147.00
Ceiling
$573,147.00
Awarded
November 28, 2025
Identifier
5R01AI121244-11
This NIH grant supports research on how autophagy affects host defense against bacterial pathogens, focusing on Salmonella enterica Typhimurium and Staphylococcus aureus, and the role of the ATG16L1 protein in infection susceptibility.
Description
The cellular degradative process of autophagy is a major host defense pathway. This project investigates the physiological mechanisms by which autophagy alters defense against two significant bacterial pathogens, Salmonella enterica Typhimurium and Staphylococcus aureus. The research aims to elucidate how autophagy and pathogen sensing control exosome biogenesis and how the ATG16L1 T300A allele impacts susceptibility to infection.