Award
NIH Reporter #5R35GM124847-10
Protein Allostery and Catalysis Beyond Bragg Diffraction
Recipient
Cornell University
Award Amount
$412,907.00
Ceiling
$412,907.00
Awarded
July 28, 2026
Identifier
5R35GM124847-10
This award supports interdisciplinary research to visualize and understand protein motions related to allostery and catalysis using advanced structural and computational methods.
Description
The project aims to understand how protein motion gives rise to function by applying scattering-based structural methods and developing computational techniques to interpret conformational disorder. It includes extracting dynamic information from protein crystals, mapping structural interconversions of allosteric and flexible enzymes, and integrating cryo-electron microscopy with X-ray methods to study protein motions that control catalysis.