Award
NIH Reporter #5R00CA255586-04
Exploring O-glycoproteomics to prevent metabolic radioresistance in the tumor microenvironment
Recipient
Not Specified
Award Amount
$249,000.00
Ceiling
$249,000.00
Awarded
February 05, 2026
Identifier
5R00CA255586-04
Research project funded by the National Cancer Institute to study metabolic changes in cancer cells that lead to resistance to radiotherapy, aiming to identify and modulate protein modifications that contribute to this resistance.
Description
This project focuses on metabolic reprogramming toward the hexosamine biosynthesis pathway (HBP) in cancer, particularly in Cancer-Associated Fibroblasts (CAFs), which increases protein O-glycosylation and modulates radioresistance. The research aims to identify proteins that are O-glycosylated after MR toward HBP, understand how these PTMs affect cellular behavior, and modulate radioresistance. The approach involves constructing tumor-stroma organoids.