Award
NIH Reporter #5K99HL177331-02
Identifying Druggable Genetic Factors Underlying Radiation-induced Heart Disease
Recipient
Stanford University
Award Amount
$160,818.00
Ceiling
$160,818.00
Awarded
August 21, 2026
Identifier
5K99HL177331-02
NIH grant awarded to Stanford University to research genetic factors affecting radiation-induced heart disease using stem cell models, GWAS, and CRISPR screens, aiming to develop targeted therapies.
Description
This project aims to identify genetic factors influencing individual radiosensitivity and develop protective strategies against radiation-induced heart diseases (RIHD). The research involves establishing a cell library of 96 induced pluripotent stem cell (iPSC) lines, irradiating derived cardiomyocytes, performing genome-wide association studies (GWAS), and employing CRISPR-Cas9 screens to identify key genes. Validation includes virtual drug screening and testing in engineered heart tissues and mouse models to uncover novel therapeutic targets and countermeasures to mitigate RIHD.