Award
NIH Reporter #5F30AG094191-02
Targeted lipid-siRNA complexes for SPP1-silencing in Alzheimer's Disease
Recipient
Vanderbilt University
Award Amount
$55,114.00
Ceiling
$55,114.00
Awarded
September 01, 2026
Identifier
5F30AG094191-02
Award to Vanderbilt University for developing targeted lipid-siRNA complexes to silence SPP1 in Alzheimer's Disease, aiming to reduce neuroinflammation and amyloid burden through innovative siRNA delivery platforms.
Description
This project aims to develop siRNA delivery platforms to target the neuroinflammatory gene SPP1 in perivascular cells to elucidate their role in Alzheimer's Disease and explore therapeutic interventions. The research focuses on reducing neuroinflammatory and amyloidogenic hallmarks of the disease using targeted lipid-siRNA complexes.