Award
NIH Reporter #11264782
Antibodies against Oxidized Phospholipids and Osteoporosis
Recipient
Central Arkansas Veterans Healthcare System, North Little Rock, AR
Awarded
December 11, 2025
Identifier
11264782
Research project funded by Veterans Affairs to study antibody-based therapies targeting oxidized phospholipids for osteoporosis treatment and prevention, involving both animal models and human cohort studies.
Description
This project investigates the role of anti-phosphocholine (PC) antibodies, particularly E06 IgM and IgG, in the prevention and treatment of osteoporosis and other age-related diseases. The research focuses on how oxidized phospholipids (PC-OxPLs) contribute to disease pathology and how enhancing antibody responses may promote bone health.