Award
National Institute of Biomedical Imaging and Bioengineering 5R01EB032655-04
A novel paradigm of sensitization of the tumor microenvironment with image-guided ultrasound cavitation and mechanotherapeutics for targeted HCC treatment
Recipient
University of Washington
Award Amount
$600,789.00
Ceiling
$600,789.00
Awarded
May 16, 2025
Identifier
5R01EB032655-04
This NIH-funded project by the University of Washington develops an image-guided ultrasound and mechanotherapeutic drug approach to improve chemotherapy delivery and efficacy in hepatocellular carcinoma treatment.
Description
The purpose of this project is to develop a novel image-guided approach for modulating the tumor microenvironment (TME) of HCC with combined mechanotherapeutic drugs (MechTx) and ultrasound cavitation treatment (USCTx), and evaluate its therapeutic efficacy. The project aims to implement USCTx and the targeting and monitoring of the combined treatment on a clinical scanner to make it widely available for future preclinical and clinical studies. The approach aims to improve chemotherapy outcomes by modulating the tumor microenvironment to promote increased local tumor uptake of chemotherapeutics, resulting in better therapy outcomes for hepatocellular carcinoma (HCC).