Award
National Institute of Neurological Disorders and Stroke 5R01NS129502-04
Role of reactive astrocytes in prion diseases
Recipient
University of Maryland Baltimore, Baltimore, MD
Award Amount
$622,545.00
Ceiling
$622,545.00
Awarded
December 09, 2025
Identifier
5R01NS129502-04
NIH research grant to study the role of reactive astrocytes in prion diseases using a conditional Stat3 knockout mouse model to understand disease progression and potential therapeutic targets.
Description
This project aims to critically examine the role of reactive astrocytes in prion disease pathogenesis, utilizing a novel mouse model for conditional knockout of Stat3 in astrocytes. The study will assess the impact of Stat3 knockout on astrocyte and microglia functions and characterize phenotypic heterogeneity of reactive astrocytes via single-nuclei RNA sequencing.