Award
National Cancer Institute 11370185
Chimeric RNA driven neopeptide vaccine for prevention of breast cancer in germline BRCA1/2 carriers
Recipient
University of TX MD Anderson Cancer Center
Award Amount
$670,898.00
Ceiling
$670,898.00
Awarded
June 16, 2026
Identifier
11370185
NIH grant awarded to University of TX MD Anderson Cancer Center to develop a vaccine preventing breast cancer in BRCA1/2 mutation carriers through identification and validation of immunogenic peptides from chimeric mRNA, with testing in mouse models.
Description
This preclinical study aims to develop a vaccine to prevent breast cancer in women with germline BRCA1/2 mutations. The approach involves genomic characterization of preneoplastic breast tissue to identify neoantigens from chimeric mRNA, coupled with bioinformatics prediction of immunogenic peptides. The project includes validation of peptides, testing in a transgenic mouse model, and elucidation of immuno-preventive mechanisms.