Award
NIH Reporter #5F31AR082689-03
The Epigenetic Regulation of Epidermal Stem Cells in Adult Skin Wound Healing
Recipient
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NEW YORK, NY, UNITED STATES
Award Amount
$23,747.00
Ceiling
$23,747.00
Awarded
March 20, 2026
Identifier
5F31AR082689-03
Research project funded by NIAMS to study epigenetic regulation by PRC1 in epidermal stem cells during skin wound healing, aiming to improve therapeutic strategies for chronic wounds.
Description
The project investigates the role of PRC1, a chromatin regulator, in wound healing, specifically its regulation of epidermal basal cell migration via repression of E-cadherin and control of epithelial-mesenchymal plasticity (EMP). The research aims to elucidate mechanisms of epidermal re-epithelialization and identify potential targets for improving wound healing.