NIH Reporter #1R21HD118466-01A1

Optimizing Minoxidil Delivery for Persistent Elastin Deposition in the Murine Vaginal Wall

Research project funded by NICHD to optimize minoxidil delivery for enhancing vaginal elastin production in mice, aiming to develop a treatment for pelvic organ prolapse.

Description

This project aims to develop a biologically motivated treatment to facilitate de novo vaginal elastogenesis by optimizing the local administration of minoxidil, a potassium channel opener, to the vaginal wall. The research will investigate the effects of dosage, delivery method, and treatment duration on elastin production and fiber persistence in mice, using biomechanical and biochemical assays. The goal is to demonstrate the therapeutic potential of minoxidil to generate vaginal elastic fibers in vivo, improving biomechanical stability and women’s health.

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