Award
NIH Reporter #5K08HL159289-05
Engineered microsystems to assess endothelial contribution to myeloproliferative neoplasm thrombosis
Recipient
University of Minnesota
Award Amount
$171,180.00
Ceiling
$171,180.00
Awarded
July 31, 2026
Identifier
5K08HL159289-05
This award supports research to understand and reduce thrombosis in patients with JAKV617F+ myeloproliferative neoplasms by targeting endothelial cell signaling pathways using engineered microsystems.
Description
The project aims to determine whether reducing JAKV617F+-mediated signaling using JAK-STAT and Gas6-Axl-MERTK inhibitors decreases thrombosis in myeloproliferative neoplasms (MPNs) and establish a mechanistic rationale for novel antithrombotic therapies using endothelialized microfluidics models to assess endothelial function.