Award
National Institute of General Medical Sciences 5R35GM156195-02
Mechanisms and consequences of lipid accumulations in necroptosis
Recipient
State University of New York at Buffalo
Award Amount
$397,771.00
Ceiling
$397,771.00
Awarded
May 04, 2026
Identifier
5R35GM156195-02
This NIH-funded project at SUNY Buffalo investigates lipid roles in necroptosis to develop lipid-centric therapies for related diseases.
Description
The project studies lipid regulation and function in necroptosis, a form of regulated cell death involved in inflammatory diseases. It aims to identify lipid modulators of necroptosis, investigate mechanisms causing lipid accumulation, and study how S-acylation regulates MLKL function, a key protein in necroptosis membrane permeabilization.