Award
National Institute of Diabetes and Digestive and Kidney Diseases 5R01DK139541-03
Structural Mechanisms of Polycystic Kidney Disease Proteins
Recipient
University of Utah
Award Amount
$660,667.00
Ceiling
$660,667.00
Awarded
May 05, 2026
Identifier
5R01DK139541-03
NIH awarded a research grant to University of Utah to study the structure and function of polycystic kidney disease proteins to advance understanding and treatment of related genetic disorders.
Description
This NIH research grant aims to elucidate the structural principles and channel properties of polycystic kidney disease proteins, which are involved in autosomal dominant polycystic kidney disease, biliary atresia, and congenital heart defects. The project will determine structures and stoichiometry of relevant protein complexes, develop biomarkers, and inform therapeutic development.