Award
National Institute on Aging 1R01AG097492-01
Endothelial TLR2/4 signaling in sex dimorphism of pathological angiogenesis and aging
Recipient
Cleveland Clinic Lerner College of Medicine
Award Amount
$659,309.00
Ceiling
$659,309.00
Awarded
December 12, 2025
Identifier
1R01AG097492-01
The award supports research investigating how endothelial TLR2 and TLR4 signaling pathways contribute to sex differences in vascular inflammation, angiogenesis, and aging, with the goal of understanding mechanisms underlying sex-specific vascular pathologies.
Description
This project aims to elucidate the molecular basis of sex-dependent differences in endothelial cell functions that may shape the outcomes of angiogenesis-driven diseases and aging. It focuses on the role of Toll-like receptors TLR2 and TLR4 in vascular inflammation and sex differences, using transgenic mouse models, pharmacological approaches, and proteomics.