Award
NIH Reporter #PA-23-260
Dissecting a novel role of FAK in modulating immunity during metastatic reactivation and progression
Recipient
Columbia University Health Sciences
Award Amount
$52,068.00
Ceiling
$52,068.00
Awarded
July 30, 2026
Identifier
PA-23-260
Research project funded by the National Cancer Institute to study how FAK modulates immunity during cancer metastasis, aiming to develop new therapies to prevent metastatic relapse.
Description
This project investigates the role of focal adhesion kinase (FAK) in promoting metastatic reactivation and immune evasion in cancer, focusing on the suppression of innate immune signaling via the Sting pathway. The research aims to understand the structural and mechanistic basis of FAK's role in tumor immunobiology and to test novel therapeutic approaches to reduce metastatic relapse.