Award
National Institute of General Medical Sciences 5R35GM142786-05
MECHANISMS DRIVING THE FORMATION OF POST-OPERATIVE PERITONEAL ADHESIONS
Recipient
UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
Award Amount
$362,500.00
Ceiling
$362,500.00
Awarded
May 14, 2025
Identifier
5R35GM142786-05
NIH grant awarded to study molecular mechanisms driving post-operative peritoneal adhesions to improve treatment and survival outcomes.
Description
This NIH grant supports research on molecular mechanisms of peritoneal adhesion formation, with potential implications for fibrosis treatment and post-operative care. The study aims to identify therapeutic targets to prevent or treat adhesions, thereby increasing post-operative survival. The research focuses on PDGF signaling pathways, mechanotransduction, and the activity of MRTFs and YAP1 in cell types such as fibroblasts and VSMCs, using innovative in vivo techniques and patient tissue validation.