Award
National Institute of General Medical Sciences 5R35GM150625-04
Using Experimental Evolution to Evaluate Environmental Effects on Microbial Mutation and Adaptation
Recipient
Vanderbilt University
Award Amount
$396,127.00
Ceiling
$396,127.00
Awarded
July 31, 2026
Identifier
5R35GM150625-04
A research project funded by NIGMS to study microbial adaptation and mutation under varying oxygen conditions using experimental evolution techniques.
Description
This project investigates how oxygen availability influences microbial evolution under feast/famine conditions. It employs experimental evolution with Escherichia coli and Lactobacillus crispatus, characterizing adaptive mutations, fitness outcomes, and diversification patterns. The study aims to deepen understanding of microbial adaptation in anaerobic and aerobic environments, focusing on the human microbiome.